“…Nevertheless not my will, but Yours be done.”  Luke 22:42

To be in the center of God’s will is the safest, the only place for a child of God.  It is here where all is peace and joy no matter what the circumstances.  It is here where,
“…we know that for those who love God all things work together for good. For those who are called according to His purpose.”  (Romans 8:28)  no matter what the circumstances.
It is here where true worship springs forth.  It is here where the presence of Christ dwells. It is here where the Believer can continuously know the presence of Christ.

The question is:  “How do we know what the will of God is?”
The Apostle Paul helps us here as we see in Romans 12:2,
“…Be transformed by the renewing of your mind, that you may prove what is the good and acceptable and perfect will of God.”
“…But understand what the will of the Lord is.”  Ephesians 5:17
“This is the will of God, your sanctification…”  1 Thessalonians 4:3
“Through …the washing of water by the word.”  Ephesians 5:26

We are to be separated from the world -- in reality we are already separated from this world when we are born anew.  We are a new creation no longer of this world though we are temporarily still in it.  Therefore our walk -- how we conduct ourselves is vital.  
Ephesians 5:15-17 speaks of this very thing and ends with the words stated above,
“Therefore be careful how you walk, not as unwise men (women, too), but as wise, making the most of your time, because the days are evil.  So then do not be foolish, but understand what the will of the Lord is.”

The same is true of the whole of Romans 12:2 mentioned above.
“And do not be conformed to this world, but be transformed by the renewing of your mind, that you may prove what the will of God is, that which is good and acceptable and perfect.”

Yes, we are separated from this world and it is the Holy Spirit who convicts and convinces, who leads and guides, who reveals to us God’s Word.  
 Paul prayed continuously that,
“…you may be filled with the knowledge of His (God’s) will in all spiritual wisdom and understanding.”  Colossians 1:9

Jesus promised that the Holy Spirit,
“…will teach you all things…”  John 14:26
And,
“I have many more things to say to you, but you can not bear them now.  But when He, the Spirit of truth, comes He will guide you into all the truth…”
John 16:12-13

How do we know God’s will?
By prayerfully and diligently seeking with a heart open before God  for His revelation.  God has made provision that each may know His will.  We have the Word and the Spirit!  Do we have a heart that is seeking?  
Amen